The absolute beauty of this program is that there is such a low and pure dose of Goldenseal, Echinacea, and other immune modulators in the formulas that they do not overstimulate the immune system and are safe for autoimmune conditions. ***We have used them in private practice with hundreds of autoimmune cases to successful be the first step in reversing the disease(Lupus, Hashi's, Graves, RA, MS, etc.) with lab work to back it up, so our experience is that the benefits far outweigh the risks and that quality and quantity are everything.