The lump in the throat sensation is most often neurological based on emotional issues.  It's a well known condition where people say that they "felt a lump in their throat".  So first consider emotional blockage, e.g. inability to articulate a feeling, a suppression of 'voice' by an overbearing person (usually a parent or significant other), and fear of speaking one's mind due to some circumstance.

Beyond that, some people can feel discomfort from the thyroid gland if it's swollen. In my clinical experience, if not from physiological causes, e.g. inflamed vocal cords, swollen thyroid, then it's a blocked emotion that needs safe expression. Pursuant to that, the Neurosyn formula could play a significant role.  Also, topical essential oils.