Yes, having Polycystic Kidney Disease, it's very important to keep your liver as healthy as possible. The program is gentle and phase one of our supplements should set you up to not have your kidneys need to work too hard. Make sure to drink plenty of water on Gut Thrive and it's highly suggested that you do a 1/2 hour consult with Jack before the pathogen purge as I have the feeling he could put you on 2 stellar kidney formulas (Ks and KDIR). Our proteolytic enzymes in phase I will help as well. Lots of parsley while on Step 2 of the Path Purge to also support the kidneys.