Does it matter whether the botanicals are taken with or without food? Sometimes I am eating mid-AM or mid-afternoon and don’t want to miss taking them 2 x day.

They work both ways. Away from food makes them a bit stronger. They have a stronger impact, but some tummies might be sensitive. Food serves as a gentle buffer. We know that sometimes timing is difficult, and you can forget, or need to make taking the supplements more convenient. So don’t worry if here and there you take them with food. They will be better served in your body, then not taken at all.