You want to open the capsules and mix into about 2 cups of water right before you're ready to do the enema, and then pour the mixture into your enema bag. The water should be lukewarm or at room temperature for comfort.

If you haven't already tried it, you may also want to start with one capsule, see how you do, and work up to the full dose if not adversely affected. Some  participants, especially from Plan S, are going to be more sensitive and need to add probiotics even later in the process.

Christa recommends holding the enema for 15 minutes. So if you are having trouble holding the enema, you could try starting off with 8 oz. of water and reducing the dosage accordingly, or you may want to try doing a plain water enema just prior to your ProbioMed 100 enema, as it can help to hold the second enema longer. This should improve the more you do it.

Christa actually went over this as part of the Q&A in Webinar #7. So if you haven't already, do take a look at that as well.