Supplements with/without food: Does "with" breakfast/supper mean to take with food, and "before" mean before eating anything? Also to clarify the "mid-morning/afternoon" and "before bed" directions— should these all be taken without food?

The “mid-morning/afternoon" and “before bed” supplements are intended to be 45 minutes away from food in either direction for maximum impact. With food can be right at the start of your meal or during your meal.